* From East:
Take Autobah 3 and exit onto Kreuz Wiesbaden. Continue on Kreuz Wiesbaden to Autobahn 66. Proceed toward Frankfurt to the Eschborner Dreieck. Then take Autobahn 648 toward Messe / Hauptbahnhof.
* From Southwest :
Take Autobahn 5 to Frankfurt Kreuz. Continue on Frankfurt Kreuz to Autobahn 3 toward Offenbach / Wuerzburg. Take the Frankfurt Sued Exit toward Stadtmitte / Hauptbahnhof.
* From North :
Take Autobahn 5 to and Exit onto Kreuz Frankfurt West. Proceed toward Messe / Hauptbahnhof.
* From South :
Take Autobahn 3 and exit onto Kreuz Wiesbaden. Proceed on Kreuz Wiesbaden to Autobahn 66 toward Frankfurt. Continue to Eschborner Dreieck, then take Autobahn 648 toward Messe / Hauptbahnhof.
